Identified with SD-OCT the morphological features of Large Colloid Drusen (LCD). This is a recently identified subgroup of early-onset drusen. In a study published in Retina, Dr. Benjamin Guigui and his staff at the University Eye Clinic in Créteil subjected 22 eyes of 11 patients to a complete SD-OCT eye examination. At the time of diagnosis, the average age of the patients was 35 years and the average visual acuity was 20/25. In all eyes examined, SD-OCT identified multiple, dome-shaped detachments of the retinal pigment epithelium at the drusen. The average height of the drusen was 199 ?m and the average width 419 ?m. All drusen appeared convex with medium and homogeneous internal reflectivity. The retina above the LCDs appeared wavy and thinned overall. A diffuse and prominent hyperreflective haze in Henle's fibre layer above the drusen was present in 73% eyes. No cases of geographic atrophy or choroidal neovascularisation were detected. These peculiar data detected by SD-OCT provide an initial insight into the ultrastructure of LCDs, which may be followed by further studies for follow-up and histological evaluation of LCDs to confirm their clinical significance.
See the article published in the issue of Retina of July/August 2013.
Dr. Carmelo Chines
Direttore responsabile
English 
Italian